Chicago White Sox vs Cleveland Guardians Prediction, Odds and Picks for Today, 09/14/25
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White Sox vs Guardians Pickswise Expert Predictions
The Chicago White Sox face off against the Cleveland Guardians in a matchup that consists of two starting pitchers both falling below the 10th percentile in xERA. Yoendrys Gomez (5.05 ERA, 1.51 WHIP) takes the mound for Chicago and has been far from consistent ever since transitioning from the L.A. Dodgers’ bullpen to the White Sox rotation. His counterpart Slade Cecconi (4.45 ERA, 1.25 WHIP) is fresh off his best start of the season, but surrendered 25 earned runs in 30 innings of work in a stretch prior to that game. Furthermore, Cecconi falls in the 5th percentile in xBA and only 16th percentile in pitching run value.
Neither starting arm is reliable, and the offenses have done enough recently that suggests they can put runs on the board in this matchup. For example, Cecconi gave up 5 ER in just 3.0 innings of work last time against this Chicago squad. The White Sox are in the top-half of the league when looking at wRC+ and wOBA over the last 14 days. With all things considered, I’ll take the over in this matchup.
White Sox vs Guardians prediction: Over 8 (-108) available at time of publishing. Playable up to 8.5 (-110).
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Ryan Bunnell
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