Chicago White Sox vs Detroit Tigers Prediction, Odds and Picks for Today, 09/06/25

The White Sox took the first game of this series by a score of 7-5 on Friday night. The Chicago lineup was rolling, as they plated 7 runs on 11 hits. But life may be a bit more difficult for the White Sox on Saturday as they go up against Tarik Skubal. The reigning American League Cy Young winner is absolutely dialed in right now, as he’s allowed just 1 earned runs over his last 3 starts and 20.2 innings. The Tigers have won 5 of his last 6 starts, and after dropping 3 of 4 games since his last start, Detroit will be more than happy to send Skubal to the mound in this one.

Veteran left-hander Martin Perez will oppose Skubal on the mound. Perez has been effective in a small sample size this season, owning a solid 2.16 ERA and 0.98 WHIP through 41.2 innings. However, his ERA goes from 1.67 at home to 3.07 on the road, and his BAA goes from .154 to .214. Those are still solid numbers, but the Tigers have crushed left-handed pitching all season long. In fact, Detroit leads the league with a team batting average of .270 against lefties, and ranks second with a .786 OPS. With Skubal on the mound, take confidence backing the Tigers -1.5 at home.

White Sox vs Tigers prediction: Tigers -1.5 (-130) available at time of publishing. Playable to -140.

If you’re looking for a new sportsbook for the football season, we recommend checking out Fanatics Sportsbook. New users can get up to $100 back in FanCash EVERY GAMEDAY UNTIL OCTOBER if their football bet loses! Join Fanatics Sportsbook, where you can bet on our White Sox vs Tigers predictions.