Chicago White Sox vs New York Yankees Prediction, Odds and Picks for Today, 09/23/25

The Chicago White Sox head to New York looking to play spoiler against a Yankees team fighting to win the AL East. The Yankees sit two games behind the Toronto Blue Jays and can’t afford to lose a series against a struggling White Sox team. Chicago has lost eight of their last ten games and are averaging only 2.6 runs per game during that stretch. 

Taking the mound for New York will be Luis Gil who enters with a 4-1 record and a 3.33 ERA. He’s been excellent for the Yankees this season, despite a slight hiccup in his last start against the Twins where he allowed four earned runs on nine hits in just 4.2 innings pitched against the Twins. For Chicago, Shane Smith will get the nod, entering with a 6-8 record and a 4.06 ERA. Smith did pitch well against the Yankees in his last outing, however, this Yankees team has been red hot averaging 5.5 runs per game in their last 10. Look for New York to handle business in this series opener and move closer to clinching a postseason berth.

White Sox vs Yankees prediction: Yankees -1.5 (-120) available at time of publishing. Playable at that number.