Chicago White Sox vs New York Yankees Prediction, Odds and Picks for Today, 09/23/25

The Chicago White Sox head to New York looking to play spoiler against a Yankees team fighting to win the AL East. The Yankees sit 2 games behind the Toronto Blue Jays and can’t afford to lose a series against a struggling Chicago squad. The Sox have lost 8 of their last 10 games and are averaging only 2.6 runs per game during that stretch. 

Taking the mound for New York will be Luis Gil, who enters with a 4-1 record and a 3.33 ERA. He has been excellent for the Yankees this season despite a slight hiccup in his last start against the Twins in which he allowed 4 earned runs on 9 hits in just 4.2 innings pitched against the Twins. For Chicago, Shane Smith will get the nod. He is 6-8 with a 4.06 ERA. Smith did pitch well against the Yankees in his last outing, however, but the Yanks have been red hot — averaging 5.5 runs per game in their last 10. Look for New York to handle business in this series opener and move closer to clinching a postseason berth.

White Sox vs Yankees prediction: New York -1.5 (-120) available at time of publishing. Playable at that number.

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