Chicago White Sox vs Pittsburgh Pirates Prediction, Odds and Picks for Today, 07/18/25

The White Sox and Pirates are set to begin their respective second halves with a Friday night matchup at PNC Park. The White Sox ended the first half with 32 wins, which was the fewest in the American League. Pittsburgh’s 39 wins are the third-fewest in the National League. While they have the better overall record, the Pirates are a tough team to trust right now. They ended the first half on a rough note, as they picked up just 1 win in their last 9 games prior to the All-Star break.

Chicago will send Jonathan Gannon to the mound. His 4.44 ERA and 1.44 WHIP aren’t other-worldly, but the White Sox have won each of his last 3 starts. Gannon has allowed 5 earned runs in 13.1 innings over that span, and could in line to put together a strong outing. The Pirates have hit the fewest home runs in all of baseball, and their team OPS of .497 is the lowest in baseball in the month of July. Both teams could be in line for long second halves, but the White Sox are the team to back at plus-money in this interleague matchup.

White Sox vs Pirates prediction: White Sox ML (+140) available at time of publishing. Playable at that number.

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