Chicago White Sox vs Washington Nationals Prediction, Odds and Picks for Today, 09/26/25

The White Sox and Nationals are set to begin the final weekend of the 2025 MLB season with a three-game series at Nationals Park. The series opener on Friday night pits Chicago’s Yoendrys Gomez against Washington’s Cade Cavalli. Gomez came to Chicago from the Dodgers earlier this summer and has transitioned to a starting role with the White Sox. It’s been an up-and-down journey thus far, as he owns a 4.46 ERA and 1.25 WHIP through 42.1 innings with his new team. The good news is that he is set to face a Washington lineup that ranks 20th in the league in total runs scored this season. The Nationals don’t hit a ton of home runs, and stringing together big innings has been a struggle for the young Nationals.

Cavalli has been excellent at home this season. Making his 10th start of the season in this one, the 27-year-old right-hander sports a strong 2.11 ERA and .218 BAA in 4 outings at Nationals Park. The White Sox rank 24th in total runs scored so far in September, and like Washington, have struggled to score runs on a consistent basis in 2025. Both teams are well outside playoff contention and are just looking to get through the final weekend of the season at this point. Look to the under.

White Sox vs Nationals prediction: Under 8.5 (+100) available at time of publishing. Playable to -105.

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