Chicago White Sox vs Washington Nationals Prediction, Odds and Picks for Today, 09/27/25

In this game, we will see the Chicago White Sox take on the Washington Nationals. Last night we saw a high scoring affair with the White Sox winnings the game 10-9. On the mound today, we have Sean Burke of the White Sox and Jake Irvin of the Nationals. Burke has struggled all season with a 4.29 ERA and a 4-11 record. Through his last 3 starts, he has pitched 12.1 innings giving up 13 hits and 6 earned runs. He will go up against a Nationals team that is hitting the ball well. They are batting .242 with 28 runs over the past 6 games. They also accumulated 13 hits last night. The biggest issue with Burke is that he does not go deep into games, as he has not finished the 5^th inning in 5 straight starts. This puts unnecessary pressure on the bullpen.

For the Nationals, Irvin will take the mound. Irvin has been bad all season with a 5.69 ERA. Through his last 4 starts, he has pitched 19.2 innings giving up 24 hits and 17 earned runs. These are very normal numbers for Irvin since the beginning of August. Outside of Irvin, the Nationals bullpen ranks last in the MLB with an ERA of 5.61 on the season. Making matters worse, the Nationals bullpen has given up 14 runs over the past 4 games. Even though the White Sox don’t hit the ball well, they have a shot today. Overall, I am giving the pitching edge to Burke and the White Sox. I am taking the White Sox to get their 60^th win of the season.

White Sox vs. Nationals Prediction: White Sox ML (+100) available at the time of publishing. Playable at that number.