Cincinnati Reds vs Chicago Cubs Prediction, Odds and Picks for Tuesday, 08/05/25

Zack Littell (3.58 ERA, 1.12 WHIP) makes his first start in a new uniform since being acquired by the Cincinnati Reds prior to the trade deadline. He’ll face off with Shota Imanaga (3.25 ERA, 1.04 WHIP) as his opposition in a matchup that will see limited scoring opportunities. With nearly 10+ mph winds blowing in directly toward home plate and a pair of quality, consistent starting arms on the bump, the under is in play even with a relatively low total set for this matchup.

The Reds have been significantly worse off when facing left-handed pitching, ranking 26th in wRC+ and 24th in wOBA against lefties this season. While the Cubs’ offense has much stronger splits in this matchup against righties like Littell, the unit has slowed down as of late, falling below league average with a 96 wRC+ and .304 wOBA over the last 14 days. With a windy matchup at Wrigley Field, I’ll take the under.

Reds vs Cubs prediction: Under 7.5 (-105) available at time of publishing. Playable at that number or better.

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