Cincinnati Reds vs Milwaukee Brewers Prediction, Odds and Picks for Today, 09/28/25

The Milwaukee Brewers and Cincinnati Reds meet this afternoon for a matchup loaded with playoff implications. These division rivals have plenty of history, and Milwaukee would love nothing more than to spoil Cincinnati’s playoff hopes. It’s do-or-die for the Reds this afternoon as they hold the final NL Wild Card spot and they’ll look to give it their all in hopes to extend their season. 

Brady Singer will take the mound for Cincinnati, entering with a 14-11 record and a 3.95 ERA. The Brewers will counter with Freddy Peralta who enters with a 17-6 record and a 2.68 ERA. The last time Peralta faced the Reds, he allowed three earned runs on seven hits in a loss on June 3. Singer also fell to Milwaukee earlier this season, giving up three runs on four hits back on June 2. Offensively, the Reds are hitting the ball slightly better than the Brewers right now, averaging 3.8 runs per game in their last 10 compared to Milwaukee’s 3.1. The Reds have a lot to play for today and I think they’ll complete the sweep this afternoon and celebrate as they clinch the final playoff spot.

Reds vs Brewers prediction: Reds ML (+125) available at time of publishing. Playable at that number.