Cincinnati Reds vs San Diego Padres Prediction, Odds and Picks for Today, 09/08/25

In this game, we will see the Cincinnati Reds take on the San Diego Padres. The Reds are looking to make a push for a playoff spot, while the Padres are trying to win their division. On the mound today, we have Nick Lodolo of the Reds and Yu Darvish of the Padres. Lodolo struggled in his most recent start, giving up 4 runs through 4.2 innings against the Dodgers. This makes it 2 starts in a row that Lodolo has not made it through the 5th inning. This is concerning when realizing that the Reds’ bullpen has given up 9 runs over the past 4 games and 20 runs in the last 5, if we count their full bullpen game. It does not help that Lodolo and the Reds go up against a Padres lineup that is batting .269 over the past 6 games. This lineup has also tallied 31 hits and 18 runs over the past 2 games. With the bats working for the Padres, it may be another short night for Lodolo.

For the Padres, Darvish will take the mound. Darvish has also had some difficulties in making it through the 5th inning. He has gone 4 innings in 3 of his last 4 starts. With these numbers, it would be no surprise for a Reds lineup that is batting .271 over the past 6 games to shut Darvish down early. With both pitchers potentially set for a short night, it puts emphasis on the bullpens. The Padres’ bullpen has been statistically the best all season with a 3.12 ERA. The Padres are also rocking a 43-25 home record this season. I am rolling with San Diego to get the win today.

Reds vs Padres prediction: Padres ML (-140) available at time of publishing. Playable at that number.

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