Cincinnati Reds vs San Diego Padres Prediction, Odds and Picks for Today, 09/10/25

The Cincinnati Reds turn to left hander Andrew Abbott, who has quietly developed into one of the more reliable pitchers in the National League this season. Abbott enters this matchup with a sharp 2.88 ERA and 1.15 WHIP across 143⅔ innings, backed by 130 strikeouts in 25 starts. His consistency has been notable, posting a 3.30 ERA over his last 15 outings, and he’s been especially effective at keeping traffic off the bases while limiting damage in big spots. Abbott’s ability to mix speeds and attack both sides of the plate has given opposing lineups fits, and Cincinnati’s opportunistic offense has often given him the support needed to secure wins during their September playoff race. With Abbott working at home in a favorable spot, the Reds have reason to be confident they can keep San Diego in check early.

For the Padres, veteran Nick Pivetta counters with strong overall numbers, carrying a 13–5 record, 2.85 ERA, and 0.96 WHIP. He’s struck out 172 batters this season and has been a stabilizing presence in San Diego’s rotation. Pivetta has historically struggled against the Reds, going 0–4 with a 6.48 ERA in six career appearances. Those trends could come into play again here, especially with Cincinnati’s lineup showing signs of life against right handers. While both pitchers are capable of quality outings, Abbott’s recent form and Pivetta’s track record against Cincy tilt the edge toward the Reds on the Money Line, making them the sharper side in this matchup.

Reds vs Padres Prediction: Reds ML (+125) available at time of publishing. Playable to that number

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