Cincinnati Reds vs St. Louis Cardinals Prediction, Odds and Picks for Today, 09/15/25

The Cincinnati Reds will give the ball to Zack Littell, who has been a steady presence in their rotation this season. Littell enters with a 9-8 record, 3.78 ERA, and 1.12 WHIP, striking out 120 while limiting walks and hard contact. He doesn’t overpower hitters, but his consistency and ability to navigate lineups without giving up big innings has made him a dependable arm. Cincinnati’s offense has had its ups and downs, but the combination of Elly De La Cruz’s speed and power with Spencer Steer’s steady production has kept them competitive in tight games. Littell’s reliability gives the Reds a chance to dictate the pace, especially early on.

The St. Louis Cardinals counter with Matthew Liberatore, who has endured an inconsistent 2025 but remains a capable starter. Liberatore holds a 7-12 record with a 4.35 ERA and 110 strikeouts across the season. He can keep opponents in check when his command is sharp, but he’s also prone to allowing baserunners and the occasional big inning. St. Louis’ lineup, led by Alec Burleson, Willson Contreras and Nolan Arenado has shown flashes of power, yet overall run production has been streaky. With Littell’s steady profile and Liberatore’s ability to battle through lineups despite occasional hiccups, this game projects more as a pitcher’s duel than a shootout. Both rotations should be able to limit damage enough to keep scoring controlled, so let’s back the under here.

Reds vs Cardinals Prediction: Under 8.5 (-110) available at time of publishing. Playable to that number

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