Cleveland Guardians vs Arizona Diamondbacks Prediction, Odds and Picks for Today, 08/18/25

The Guardians hit the road to face the Diamondbacks at Chase Field on Monday night. Cleveland heads west after a 6-game home stand that saw them go 2-4 and score just 5 total runs in their 3-game series against Atlanta over the weekend. Now, they prepare to face Arizona right-hander Zac Gallen. Gallen has had a tough time in 2025, but he is putting together a strong August o far. The 30-year-old right-hander has allowed just 6 earned runs over 3 starts and 17 innings, with the Diamondbacks winning all three games. He could be in line for another solid outing against a Cleveland offense that struggled over the weekend.

Cleveland’s Gavin Williams will get the start on the mound for the visitors. Williams’ ERA goes from 3.18 at home to 3.60 on the road, and he is coming off an outing in which he allowed 4 earned runs on 5 hits over just 3 innings against the Marlins. Arizona’s offense continues to score runs on a consistent basis, and they should be able to help Gallen out with some run support in this one. Let’s back the Diamondbacks at home.

Guardians vs Diamondbacks prediction: Arizona ML (-120) available at time of publishing. Playable to -125.

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