Cleveland Guardians vs Boston Red Sox Prediction, Odds and Picks for Tuesday, 09/02/25

The Cleveland Guardians and Boston Red Sox play the second game of their series on Tuesday night. The Sox took Monday’s game, 6-4, as the entire top half of the lineup was collecting hits doing damage. On Tuesday, the Sox send their ace to the mound in a prime spot, and this game should be an easy win for the Sox. It is baseball, and baseball rarely does what it is supposed to do, but there is no reason Boston shouldn’t roll in this one. My Guardians vs Red Sox prediction is the Red Sox -1.5.

It will be Garrett Crochet on the bump. Crochet is continuing to put together a Cy Young-worthy season, piling up Ks and leading his team to wins. When he faces the Guardians tonight, he will face the team that has the second lowest slugging percentage vs lefties on the season. And that is against lefties in general; he is one of the best. The Guards’ lineup has either never seen Crochet or has only seen him a couple of times, and no one has had success against him yet. On the other side, the Red Sox are a top ten offense vs righties, and Slade Cecconi is a very average arm. There is no reason for the Sox not to score plenty of runs, so give me Boston to cover.

Guardians vs Red Sox Prediction: Red Sox -1.5 (-120) available at the time of publishing. Playable at that number.

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