Cleveland Guardians vs Detroit Tigers Prediction, Odds and Picks for Today, 09/17/25

The Guardians and Tigers played an extra inning affair on Tuesday that resulted in a 7-5 Guardians win. Both teams burned through a lot of bullpen arms, as Cleveland used six different relievers and Detroit utilized four. With that in mind, it will be interesting to see who is available in each bullpen on Wednesday night. Detroit will send Jack Flaherty to the mound, and the 2025 season has not been kind to him. The veteran right-hander enters this contest with a 4.69 ERA over 151.2 innings of work this season. He is coming off a decent outing in which he tossed 5 scoreless innings against the Yankees, but given his season-long inconsistencies, it’s tough to expect that kind of performance in back-to-back starts.

Opposing Flaherty on the mound will be Cleveland left-hander Logan Allen. Like Flaherty, Allen has seen his fair share of struggles this season. He owns a 4.43 ERA through 144.1 innings this season. The Tigers have hit lefties well all season, and they enter this contest ranking second in the majors with a .788 OPS against southpaws. This could be another high-scoring affair. Look to the over.

Guardians vs Tigers prediction: Over 8.5 (-110) available at time of publishing. Playable to -115.