Cleveland Guardians vs Los Angeles Dodgers Prediction, Odds and Picks for Today, 03/31/26

The Cleveland Guardians took the first game of this series against the Los Angeles Dodgers by a score of 4-2 on Monday night. Now, the Dodgers are looking to bounce back from their first loss of the season. Los Angeles should feel good about its chances, as Shohei Ohtani is slated to make his first start of the season on the mound. Ohtani didn’t toe the rubber until June 16 last season, but he posted a strong 2.87 ERA and allowed just 40 hits while striking out 62 in 47.0 innings of work. It will be interesting to see how many innings he tosses in this one, but Ohtani should be able to put the Dodgers in a strong position against a Cleveland offense that has been boom or bust early on this season.

On the other side, Tanner Bibee will take the mound for the Guardians. The 27-year-old right-hander was the Opening Day starter for Cleveland, and he allowed 3 solo home runs over 5.0 innings against Seattle. The Dodgers have blasted 5 home runs through their first 4 games of the season, and possess the most well-rounded lineup in baseball. Coming off their lowest-scoring performance of the season, look for the Dodgers to be aggressive against Bibee. They should be able to do some damage early while Ohtani holds things down on the mound. Back LA on the run line -1.5.

Guardians vs Dodgers prediction: Dodgers -1.5 (-110) available at time of publishing. Playable at that number.