Cleveland Guardians vs Minnesota Twins Prediction, Odds and Picks for Today, 09/20/25

In this game, we will see the Cleveland Guardians take on the Minnesota Twins. The Guardians are making a heavy push for the playoffs by winning 13 of their last 14 games. Jumping to today, we will see Logan Allen of the Guardians and Bailey Ober of the Twins take the mound. Allen has been okay this season with a 4.36 ERA and a 7-11 record. Through his last 2 starts, he has been a little better giving up 4 runs in 10 innings pitched. He has faced the Twins once this year where he pitched 3 innings giving up 4 hits and 2 runs. Looking at Ober, he has given up 4+ runs in 3 of his last 4 starts. He has faced off against the Guardians 3 times this year giving up 17 hits and 6 runs in 15.2 innings. Overall, neither pitcher provides us with much confidence.

Outside of the starters, both of these teams come into this one in similar hitting form. The Guardians are batting .245 with 26 runs over the past 6 games while the Twins are batting .249 with 29 runs. These similarities also don’t give us much room for an edge. Where the edge lies in the bullpens. The Guardians bullpen has been steadily climbing throughout the season to now have an ERA of 3.47. The Twins bullpen on the other hand, has a 4.70 ERA on the season which puts them in the bottom 5 in the MLB. The Guardians bullpen has also only given up 3 runs over the past 5 games and were the reason the Guardians won last night. Overall, the edge solely comes from the bullpen and the current roll that the Guardians are on. I am taking the Guardians to get another win.

Guardians vs. Twins Prediction: Guardians ML (-105) available at the time of publishing. Playable at that number.

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