Cleveland Guardians vs Seattle Mariners Prediction, Odds and Picks for Today, 03/26/26

Baseball is back and the Cleveland Guardians will travel to face the Seattle Mariners on Thursday night. The Guardians are coming into this one after finishing above .500 in spring training. On the mound, the Guardians will start Tanner Bibee. Last year Bibee regressed and had his worst season with a 4.24 ERA. Bibee gave up 170 hits and 54 walks through 182.1 innings pitched. Those numbers are rough, but what was even worse was the Guardians’ hitting last season. They had the fewest hits in MLB and ranked 28th in runs scored. I have a feeling it could be a tough night for the Guardians.

The Mariners ended spring training with a record of 11-19-1. For opening day, the M’s will start Logan Gilbert. He compiled a record of 6-6 last season with a 3.44 ERA through his 25 starts. Gilbert has remained steady over the past few seasons and should feel good about this season with the batters on the team. Last season Seattle ranked in home runs, and we can expect that those numbers will be similar in 2026. Additionally, the Mariners have the stronger bullpen — including Gabe Speier, Eduard Bazardo and Andres Munoz. Overall, the Mariners have the edge across the board and will look to get a win at home. I am taking the Mariners on the run line.

Guardians vs Mariners prediction: Seattle -1.5 (+135) available at time of publishing. Playable at that number.