Cleveland Guardians vs Seattle Mariners Prediction, Odds and Picks for Today, 03/28/26

The Cleveland Guardians and Seattle Mariners are set for the 3rd game of their 4 game series on Saturday night at T-Mobile Park. Cleveland took the season opener 6-4 on Thursday while Seattle responded with a 5-1 win on Friday. The starting pitching matchup in this one pits Cleveland’s Joey Cantillo against Seattle’s Bryan Woo, and the edge goes to Woo. The 26-year-old right-hander emerged into one of the most consistent starting pitchers in baseball last season as he posted a strong 2.94 ERA and racked up 198 strikeouts over the course of 186.2 innings of work. Woo has only faced the Guardians once in his career, which came back on June 19 of the 2024 season. He has improved vastly since then, and should be able to put together a strong outing in this one.

Aside from Jose Ramirez, this Guardians lineup is tough to predict on a night-in and night-out basis. Cleveland racked up 12 hits in the opener but had just 4 hits in Friday’s matchup. Offensive consistency may be hard to come by for the Guardians this season, and they have a tough matchup going up against such a reliable starter in Woo. Backing the Mariners -1.5 on the run line with odds of +120 is the play in this matchup.

Guardians vs Mariners prediction: Mariners -1.5 (+120) available at time of publishing. Playable at that number.