Cleveland Guardians vs Tampa Bay Rays Prediction, Odds and Picks for Today, 09/05/25

In this game, we will see the Cleveland Guardians take on the Tampa Bay Rays. Last night, the Rays won by a score of 4-2 while holding the Guardians to a total of 3 hits. On the mound today, we have Gavin Williams of the Guardians and Ian Seymour of the Rays. Williams is having a good season with a 3.26 ERA and a 9-5 record. To have a winning record with this Guardians team is impressive considering they rank last in batting average and hits on the season. This lack of hitting from the Guardians showed to be a problem yesterday and has contributed to them losing 4 of their last 5 games. If we take a deeper look, we will see that Williams is slightly worse away from home and has given up 3 runs and 7 hits in his last 8.2 innings away. I have a feeling he may feel some pressure with the hitting struggles of the Guardians against this Rays team.

For the Rays, Seymour will take the mound. Seymour is a relief pitcher that has been pushed into the starting rotation. In his last 2 starts, he has pitched 10 innings giving up 5 hits and 1 earned run. These are some impressive numbers, and they should continue against this Guardians team. On the hitting side, the Rays are batting .284 with 66 hits and 44 runs over the past 7 games. This level of hitting signifies how close they are to making a playoff run if they can hurdle the 2 games between them and the Seattle Mariners. Overall, it is hard to trust the Guardians with the hitting struggles that they have had on the season. Additionally, the Rays will be motivated to win these games to bridge the wild card gap. I am taking the Rays to get the win in this one.

Guardians vs. Rays Prediction: Rays ML (-140) available at the time of publishing. Playable at that number.