Colorado Rockies vs San Diego Padres Prediction, Odds and Picks for Today, 09/11/25

In this game, we will see the Colorado Rockies take on the San Diego Padres. Both teams are coming off losing series. On the mound, we have McCade Brown of the Rockies and Randy Vasquez of the Padres. Brown has had a rough start to his rookie season. Through 3 starts, he has pitched 9.1 innings, giving up 15 hits and 13 earned runs. He has also walked 7 batters in his 9.1 innings. These numbers are terrifying when going up against a Padres team that is batting .251 on the season and have a 44-27 record. Additionally, they have beaten the Rockies in 7 of their 9 meetings, including 3 shutout wins last series in San Diego.

For the Padres, Vasquez will take the mound. Vasquez has not been great, but he has been functional. Through his last 7 starts, he has given up 2 or fewer earned runs in 6 of them. Additionally, his numbers improve slightly at home, where he has a 3.77 ERA while surrendering 24 earned runs through 57.1 innings. This is a great spot for Vasquez, as the Rockies are batting .206 with only 15 runs over the past 6 games. If we look outside of the starters, the Rockies bullpen has an ERA of 5.27, while the Padres bullpen leads the league with an ERA of 3.13. Overall, the Padres have the edge across the board. I am usually not one to take the run line, but today we are on the Padres -1.5.

Rockies vs. Padres Prediction: Padres -1.5 (-115) available at the time of publishing. Playable at that number.

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