Colorado Rockies vs San Francisco Giants Prediction, Odds and Picks for Today, 09/28/25

In this game, we will see the Colorado Rockies take on the San Francisco Giants. The Giants have beaten the Rockies the last 2 nights. On the mound today, we have McCade Brown of the Rockies and Logan Webb of the Giants. Brown has had a difficult rookie season thus far. Through 6 starts he has a 7.54 ERA and a 0-4 record. He is coming off his best start, where he completed a full 5 innings and only gave up 1 run against the Seattle Mariners. The issue for Brown is that the Giants are averaging 5 runs per game over the past 6 games. I imagine it will be a rough start to end Brown’s rookies season.

For the Giants, Webb will get the start. Webb has been great this season with a 3.30 ERA and a 14-11 record. Webb has pitched twice against the Rockies this season and went 12 innings giving up 13 hits and 3 earned runs. Webb’s ability to limit runs is incredible. Up against Webb will be a Rockies lineup that is batting .185 with 16 runs in the last 6 games. The Rockies also hold the worst batting average in the MLB away from home (.204) along with the least amount of runs scored. The Rockies bullpen also ranks 29^th with an ERA of 5.22 on the season. Overall, this should be a good close to the season for Webb and the Giants. I am taking the Giants on the run line.

Rockies vs. Giants Prediction: Giants -1.5 (-140) available at the time of publishing. Playable at that number.