Colorado Rockies vs Seattle Mariners Prediction, Odds and Picks for Today, 09/23/25

There’s no team hotter than the Seattle Mariners right now, and their surge couldn’t come at a better time. With only six games left in the season, Seattle holds a three-game lead in the AL West. The Mariners have won four straight and 14 of their last 15, and with this matchup, they should be in a prime position to keep their offensive rolling and lock up a playoff berth. 

Taking the mound for the Rockies will be McCade Brown who enters with a 0-4 record and a 9.17 ERA through five starts this season. For the Mariners, Bryce Miller will get the nod, entering with a 4-5 record and a 5.58 ERA. Offensively, the Mariners are averaging 6.1 runs per game in their last 10 compared to the Rockies 3.9. The Mariners have the advantage in this matchup, however, I’m leaning towards the over. Colorado’s pitching has been a disaster this season, with the bullpen carrying a 5.27 ERA. On the other side, Miller has given up two or more runs in his last 10 starts. Look for the Mariners offense to get going early against Brown, and for the Rockies to score just a few to help push this game over. 

Rockies vs Mariners prediction: Over 8 (-110) available at time of publishing. Playable at that number.