Detroit Tigers vs Boston Red Sox Prediction, Odds and Picks for Today, 09/26/25

The Tigers were finally able to end their 8-game losing streak with a victory over the Guardians on Thursday. However, Detroit is still in a major skid, having lost 11 of its last 13 games. They’ve blown a monstrous 15-game lead in the AL Central over the past 2 months, and are now in a tie with Cleveland — although Cleveland owns the tiebreaker. Detroit will send Casey Mize to the mound on Friday night against the Red Sox in hopes of picking up a consecutive win. Mize has struggled down the stretch, but he’s set a new career-high in strikeouts and is putting together since best season since 2021.

Kyle Harrison will take the mound for the Red Sox, who aim to lock up a wild card spot. Harrison will make just his third appearance with Boston after coming over from San Francisco earlier this month. So far in a Red Sox uniform, he has allowed just one earned run on 7 hits through 9 innings of work. The Detroit offense is sputtering, which is the main reason for their recent struggles. This will have the feeling of a playoff game, as both managers could micro-manage every situation and utilize many relief pitchers. With that in mind, the under is the play.

Tigers vs Red Sox prediction: Under 8.5 (+100) available at time of publishing. Playable to -105.

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