Houston Astros vs Arizona Diamondbacks Prediction, Odds and Picks for Tuesday, 07/22/25
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Astros vs Diamondbacks Pickswise Expert Predictions
The Astros are in Arizona to take on the Diamondbacks in a Tuesday night matchup at Chase Field. The pitching matchup in this one pits a pair of lefties against one another, as Houston’s Framber Valdez and Arizona’s Eduardo Rodriguez are slated to take the mound. Both of these offenses hit lefties well, which means we could have a high-scoring affair on our hands. Houston ranks second in baseball with a .792 OPS against lefties, while Arizona ranks ninth with a .722 OPS against southpaws.
The Astros have come into the second half hot at the plate, as they have plated 24 total runs in their last 4 games. In addition to owning a 6.32 ERA and .303 BAA at home this season, Rodriguez hasn’t provided great length. He has struggled to get through 5 innings on a consistent basis, and Arizona’s bullpen has been worrisome. More specifically, Arizona’s bullpen ERA of 4.89 ranks 26th in baseball. Look for both offenses to do some damage tonight, which makes the over the play.
Astros vs Diamondbacks prediction: Over 8.5 (-105) available at time of publishing. Playable to -110.
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Connor Grootenhuis
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