Houston Astros vs Athletics Prediction, Odds and Picks for Today, 04/04/26

The Houston Astros face the Athletics again on Saturday afternoon after the A’s exploded for an 11-4 victory on Friday. Prior to Friday, the A’s were dealing with a stagnant offense in which only Shane Langeliers had been hitting. The rest of the bats came to life on Friday. On Saturday, we get 2 starting pitchers who endured rough first outings in Tatsuya Imai and Luis Morales. Both pitchers are largely unknown commodities in terms of stats and established track records. So how do we play it? I am looking for the Astros to bounce back and take the Saturday game.

Imai is new to MLB this season. His debut was going well for a couple of innings, and then it unraveled on him. We will need to wait before deciding what he really is as a major league pitcher. We know more about Morales, though. His numbers across 48 innings last season were good, but he is definitely an extreme fly-ball pitcher. All but one of his outs last week were recorded via fly ball, and his home-run rate is high to start his career. That seems like bad news when pitching at “home” in this ballpark. I look for the Astros to slug on Saturday.

Astros vs Athletics prediction: Houston ML (-115) available at time of publishing. Playable to -135.