Houston Astros vs Athletics Prediction, Odds and Picks for Monday, 06/16/25

Lance McCullers Jr. takes the mound for the Astros, aiming to bounce back after a tough outing against the White Sox where he gave up 4 runs in 5.0 innings. Still, McCullers has shown flashes of his old form, including a dominant six-inning, seven-strikeout shutout performance against the A’s earlier this month. Backed by a solid Houston lineup featuring a resurgent Jose Altuve, Jeremy Pena and Isaac Paredes, the Astros are beginning to find offensive rhythm. With a deep bullpen and more talent top to bottom, Houston enters this matchup as the clear favorite and will look to lean on experience and firepower to take control early.

The Athletics counter with right-hander Mitch Spence, who has quietly been one of the bright spots in their rotation. Spence sports a 3.67 ERA and is coming off back-to-back strong starts, including 5.0 scoreless innings against the Angels. Oakland’s recent series sweep of Kansas City shows signs of life, but they remain near the bottom of the AL West standings. While their bullpen has stabilized slightly and the offense has been scrappy, they still lack consistency. Facing a seasoned arm like McCullers and a dangerous Houston lineup, the A’s will need a near-flawless performance to keep pace. Despite Spence’s recent success, the matchup leans heavily in Houston’s favor. I think this line is a little too short even though it’s a little juicy. Regression for A’s pitching is likely and the Astros are winners in 8 of their last 10.

Astros vs Athletics prediction: Houston ML (-155) available at time of publishing. Playable to -165.

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