Houston Astros vs Atlanta Braves Prediction, Odds and Picks for Today, 09/12/25

The Houston Astros will turn to rookie Jayden Murray, who has just a taste of major-league action under his belt with 2.1 scoreless innings so far. While the early results are clean, the sample is far too small to project sustained success, and Murray is still working to refine his pitch mix against top level competition. Houston’s offense gives him some margin for error, with Yordan Alvarez, Carlos Correa and Jose Altuve anchoring a lineup capable of putting up crooked numbers in a hurry, but asking a pitcher with such limited MLB experience to hold off Atlanta’s lineup in the early innings is a tall task. If Murray can’t settle in quickly, the Astros could be playing from behind right away.

The Braves counter with Hurston Waldrep, who has quickly emerged as a dependable young arm. Waldrep owns a surprising 1.33 ERA with 38 strikeouts across 40.2 innings, showing command of both his splitter and breaking pitches while limiting hard contact. He has been particularly strong in the early frames, setting a steady tone and giving Atlanta’s potent offense — led by Ronald Acuna Jr. and Matt Olson — room to work. With Murray untested at this level and Waldrep thriving in recent outings, the Braves have a clear edge at the start of this game. The safer play is on Atlanta to control the first half behind its rookie’s hot stretch, making the the Braves a sharp pick.

Astros vs Braves prediction: Atlanta F5 ML (-110) available at time of publishing. Playable to -130.

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