Houston Astros vs Baltimore Orioles Prediction, Odds and Picks for Today, 08/21/25

The Houston Astros head to Camden Yards to open a four-game series against the Baltimore Orioles in what should be an exciting matchup. These teams just wrapped up a three-game set on August 17, with Baltimore taking two of three in that series. The Orioles have won six of their last seven and will look to keep rolling tonight as they send Brandon Young to the mound, hoping he can build on his recent success. 

On the season, Young is 1-6 with a 5.68 ERA, but in his last start against Houston, he pitched eight scoreless innings, allowing just one run and struck out six. For the Astros, Jason Alexander will get the nod who enters with a 3-1 record and 4.74 ERA. In his last start, he pitched six innings against Baltimore, allowing two earned runs on three hits. This Astros team has struggled to score runs, averaging just three runs per game over their last 13. In that same span, they have a team ERA of 5.58. For Baltimore, they hold a 2.32 team ERA while averaging 4.6 runs per game over their last 12. We’ve seen both teams have their ups and downs this season, but the Orioles are red hot right now and I don’t see the Astros getting out of their funk in this one. 

Astros vs Orioles prediction: Orioles ML (-115) available at time of publishing. Playable at that number.

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