Houston Astros vs Los Angeles Angels Prediction, Odds and Picks for Saturday, 06/21/25

The Astros managed to escape with a victory last night by scoring the go-ahead run in the top of the 10th inning and defeated the Angels 3-2. The Astros have now won 8 of their last 10; the Angels have won 5 of their last 10. Looking at tonight’s matchup, left-hander Brandon Walter will toe the rubber for Houston and he still looking for his first win of the season. In 3 starts, Walter holds a 1.53 ERA and has struck out 19 in 17.2 innings pitched. For the Angels, Jose Soriano will get the start; he is 4-5 with a 3.54 ERA on the season. 

Soriano got off to a rough start this season, but in his last 2 games he pitched extremely well — allowing just 1 earned run over 14 innings while striking out 18. Taking a look at Houston’s stats over the last 15 days, it is among the hottest teams in the league. The ‘Stros are second in runs per game, averaging 5.3 runs in their last 14; the Angels are 24th averaging 3.6 runs in that same span. Looking at pitching, the Astros have been dominant over their last 14 games — holding a team ERA of 2.69 compared to the Angels 3.57. The Astros hold an offensive advantage in this matchup and if they hold the lead late in the game, they boast one of the best bullpens in the league to finish the job. Look for Houston to roll in today’s matchup, making the Astros my best bet of the day. 

Astros vs Angels prediction: Houston ML (+100) available at time of publishing. Playable at that number.

If you’re looking for a new sportsbook, we recommend checking out Fanatics Sportsbook, where new users can bet $30 and receive $300 in bonus bets INSTANTLY! Join Fanatics Sportsbook, where you can bet on our Astros vs Angels predictions.