Houston Astros vs The Athletics Prediction, Odds and Picks for Today, 09/25/25

With the Guardians taking over first place in the AL Central, the final wild card spot in the American League is down to a fight between the Astros and Tigers. Detroit currently holds a one-game lead in the race, but both teams are slumping at the worst possible time. The Astros enter Thursday night’s matchup against the Athletics riding a five-game losing streak. Houston has scored just one run in the first two games of this series, and it doesn’t help that Framber Valdez owns a less-than-ideal 8.27 ERA over 4 September starts. No matter how you slice it, the Astros are simply not a team to trust right now.

The Athletics are looking to continue playing spoiler after taking the first two games of this series by scores of 5-1 and 6-0. The Athletics are rolling at home right now, having won six straight games at Sutter Health Park. J.T. Ginn has been impressive lately, sporting a 1.76 ERA through 3 appearances and 15.1 innings in September. He has the luxury of facing a Houston offense that looks lost at the plate right now. With the way they are going, fade the Astros and consider backing the Athletics at home.

Astros vs Athletics prediction: Athletics ML (-105) available at time of publishing. Playable to -110. 

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