Houston Astros vs Toronto Blue Jays Prediction, Odds and Picks for Today, 09/11/25

The Houston Astros and Toronto Blue Jays are set to wrap up their 3-game series this afternoon, with both teams desperate to secure a series win. The Astros find themselves just 1 game up in the AL West, while the Jays sit 3 games ahead in the AL East. Taking the mound for the Astros will be Cristian Javier, entering with a 1-2 record and a 4.43 ERA. 

For the Blue Jays, Kevin Gausman enters with a 9-10 record and a 3.63 ERA. While he holds the edge on the mound in this matchup, the last time he faced Houston on April 21, he allowed 4 earned runs on 6 hits across 6.0 innings. The Blue Jays are 46-25 at home this season, while the Astros are 36-35 on the road. The Jays’ offense is in a little bit of a slump right now, averaging just 2.5 runs per game over their last 4 — which is significantly less than their season average of 4.9. However, even the best teams in the majors cool off for a bit and the Blue Jays have a ton of talent in their lineup. I expect the Jays to get their offense going again against Javier and for Gausman to put his team in a position to pick up the win — making Toronto my best bet of the day.  

Astros vs Blue Jays prediction: Toronto ML (-155) available at time of publishing. Playable at that number.

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