Kansas City Royals vs Los Angeles Angels Prediction, Odds and Picks for Tuesday, 09/23/25

The Kansas City Royals hand the ball to Cole Ragans, who has been working to settle into a consistent groove. He enters this matchup with a 2-3 record and a 5.16 ERA and although it’s been rocky he has showed an ability to limit damage against weaker lineups. Ragans’ best outings have come when he gets ahead in the count, using his offspeed pitches to generate weak contact and keep traffic off the bases. With offensive support from the likes of Bobby Witt Jr and Salvador Perez, the Royals have shown they can manufacture runs in different ways, giving Ragans a stronger safety net when he’s on the mound. That balance between solid pitching and timely hitting has often allowed Kansas City to stay competitive in games like this.

For the Angels, Sam Aldegheri continues to learn on the job as a relatively new piece of the rotation. While he’s shown some promise, his recent outings have been inconsistent, with command lapses leading to elevated pitch counts and hard contact. His ERA and WHIP both reflect those struggles, especially against more disciplined lineups that can capitalize on mistakes. Offensively, the Angels remain streaky, relying heavily on occasional power rather than consistent production across the order. That puts more pressure on Aldegheri to be nearly flawless, something that has been difficult in his early outings. Given Ragans’ ability to mix pitches effectively, Kansas City’s steadier run production, and the Angels’ volatility, the edge leans toward the Royals finding enough offense to support their starter.

Royals vs Angels Prediction: Royals ML (-155) available at time of publishing. Playable to -160