Kansas City Royals vs San Diego Padres Prediction, Odds and Picks for Today, 06/21/25

The Kansas City Royals look to make it 5 straight wins today while the San Diego Padres are in the midst of a 2-7 stretch. Dylan Cease (4.69 ERA, 1.33 WHIP) takes the bump for the hosts looking to right the ship, and there is plenty of reason to believe he’ll bounce back after being cracked for 6+ earned runs last time out. The righty is drastically underperforming compared to his 3.47 xERA as has consistently generated a ton of swing-and-misses, falling in the 90th percentile of better in whiff % and strikeout rate.

Kansas City’s offense ranks bottom-5 in wRC+ against right-handed pitching, and it won’t get any easier when Cease is pulled as San Diego’s bullpen currently posts the sixth-best combined ERA (3.34) in baseball. With a heavier price on the money line that preferred, I’ll take the Padres to cover the run line at a plus-money price.

Royals vs Padres prediction: San Diego -1.5 (+140) available at time of publishing. Playable to +120.

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