Los Angeles Angels vs Chicago Cubs Prediction, Odds and Picks for Today, 04/01/26

The Chicago Cubs took the first game of this series by a score of 7-2 on Monday, while the Los Angeles Angels responded with a 2-0 victory on Tuesday. That sets up a rubber match on Wednesday afternoon at Wrigley Field. A pair of lefties will toe the rubber in this contest, as Los Angeles will send Yuesi Kikuchi to the mound while Chicago turns to Matthew Boyd. Neither of these offenses hit lefties well. So far this season, the Angels rank 26th in baseball hitting .158 against southpaws, while the Cubs aren’t much better — 24th hitting .194.

The Angels lead all of baseball with 10 home runs through 6 games, but it would be a bit surprising to see that success last — especially in this one. The wind is expected to be howling in during this contest, which makes home-run hitting a much more difficult task. The Cubs have been a little reliant on the long-ball early on this season, which makes it tough to expect a high-scoring affair in this one. Even with such a low total — given the fact that both offenses aren’t hitting lefties well to start the season — the under is the play.

Angels vs Cubs prediction: Under 6 (-110) available at time of publishing. Playable at that number.