Los Angeles Angels vs Houston Astros Prediction, Odds and Picks for Today, 03/26/26

The Los Angeles Angels open the season against the Houston Astros in Houston on Thursday. The Angels think they have taken a step forward this season, while the Astros seem to have taken a step backwards. This early in the season, of course, this game is priced based on how we expect these teams to fare overall, but this is a great price on a game in which the underdog could very easily win. I am sniffing around for the upset on Opening Day. Give me the Angels to win.

The pitching matchup is Hunter Brown vs Jose Soriano. Brown is the obviously better pitcher and one of the better pitchers in the league right now, but let’s not overlook Soriano. In two games vs the Astros last season, he gave up only 1 run across 13.2 innings of work. This Astros lineup has Yordan Alvarez in it to open the season, but it is not a bopper of a lineup otherwise. The Angels, on the other hand, have a deep lineup, or at least as long as their health holds up for oft-injured guys like Trout, Soler, Moncada, and Adell. The Astros are favored too heavily here; I’ll take the Angels.

Angels vs Astros prediction: Los Angeles Angels ML (+160) available at time of publishing. Playable to +130.