Los Angeles Angels vs Milwaukee Brewers Prediction, Odds and Picks for Today, 09/17/25

The Los Angeles Angels have dropped 5 straight games and scored 3 runs or fewer in each of their last 4 games. On Tuesday night, they suffered a 9-2 loss on the road against the Milwaukee Brewers, who have wins in 3 of their last 4 games. Unlike the Angels, the Brewers have been clicking offensively, scoring 8 or more runs in those 3 victories. Milwaukee enters Wednesday’s contest as significant favorites and I’m therefore making a play on the current run line. The Brewers rank inside the top 5 in both batting average and on base percentage against right-handed pitching, and they’ll be going up against Angels’ starter Jose Soriano.

Soriano owns a 4.13 ERA across 30 starts on the season, but he is coming off back-to-back starts that didn’t go in his favor. Soriano surrendered 8 earned runs and 5 walks against the Athletics on September 5 and walked 3 runners and allowed 3 earned runs across 4 innings in his latest start against the Mariners. The Brewers should be in position for some early success in this ballgame. Countering for the Brewers is right-hander Brandon Woodruff, who has looked good since returning from right shoulder surgery in July. Over 11 outings, Woodruff owns a 3.32 ERA and just tossed 6 scoreless innings with 8 punchouts in his latest start against the Pirates. The Brewers have the better lineup and the better starting pitcher on Wednesday night, so I’ll be backing them on the run line.

Los Angeles Angels vs Milwaukee Brewers Prediction: Brewers -1.5 (+110) available at time of publishing. Playable at that number.

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