Los Angeles Angels vs Seattle Mariners Prediction, Odds and Picks for Today, 09/12/25

The Los Angeles Angels and Seattle Mariners got their weekend series started with a grueling 12-inning marathon late last night. The Mariners ultimately won the game, 7-6, and extended their winning streak to 6 games. With only a few weeks left in the season, every game matters, and the Mariners are holding a playoff spot. With both bullpens being fully deployed on Thursday, look for there to be a lot of pressure on both starters to absorb innings. I expect both teams to be in a bad spot in terms of pitching, and I am playing this game total over 7.5.

On the mound are Luis Castillo and Yusei Kikuchi. Both have had recent struggles, and both have given up runs to this opponent already this season. For Kikuchi, he is in the middle of a terrible stretch where he has given up 18 runs in his last 3 starts, spanning just 17.2 innings. He hasn’t seen Seattle since late July, but he failed to make it through 5 innings that time. A short outing tonight would be trouble. Castillo had a strong start earlier this week, but that ended a run of 4 straight rough starts. He last saw the Halos in early June, but gave up 6 runs when he did. I do not have a ton of confidence in either of these starters right now, and with the bullpens getting taxed heavily on Thursday, this seems like a spot where someone is going to have to eat some innings and just take it on the chin at some point in this game, whether starter or bullpen arm.

Angels vs Mariners Prediction: Over 7.5 (-115) available at the time of publishing. Playable at that number.