Los Angeles Dodgers vs Arizona Diamondbacks Prediction, Odds and Picks for Today, 09/23/25

The Dodgers and Diamondbacks are set to begin the last week of the 2025 MLB season with an NL West matchup on Monday night at Chase Field. The pitching matchup in this one pits Los Angeles’ Shohei Ohtani against Arizona’s Brandon Pfaadt. Ohtani has been great on the mound this season, but if there’s one area of concern it’s that he has struggled when pitching on the road. His ERA jumps from 1.71 at home to 4.95 on the road, and his BAA goes from .151 to .296. Despite trading away some big bats at the trade deadline, the Arizona offense has still found success down the stretch, and should be able to get something going against Ohtani.

Pfaadt has had a forgettable 2025 season. His ERA sits north of 5.00, and opponents are hitting a strong .281 with a .792 OPS against him. He’s also struggled at home, owning a 7.29 ERA and .310 BAA at Chase Field. He tossed a complete game shutout and allowed just 1 hit in his last outing against the Giants, but given his inconsistency this season, it’s tough to expect another strong outing. All in all, both offenses could have the edge in this one. Look to the over.

Dodgers vs Diamondbacks prediction: Over 9 (+100) available at time of publishing. Playable to -110.