Miami Marlins vs Colorado Rockies Prediction, Odds and Picks for Today, 09/17/25

The Miami Marlins will hand the ball to Ryan Weathers, who is coming off one of his best performances of the season after returning from injury. In his most recent outing, Weathers tossed five scoreless innings on just 68 pitches, allowing five hits, walking none, and striking out four. For the season, he owns a 2.73 ERA with a 1.04 WHIP, showing improved command and a knack for avoiding big innings. While his workload has been somewhat limited, his ability to keep traffic off the bases and consistently get ahead in counts has given Miami stability in a rotation that’s needed it. Against a Rockies lineup that has been inconsistent and often struggles to generate sustained rallies, Weathers’ approach could allow the Marlins to set the tone early.

The Colorado Rockies counter with rookie McCade Brown, who has endured a rough transition to the majors. In his first four starts, Brown has gone 0-4 with a 9.88 ERA and 2.12 WHIP, walking too many hitters and struggling to put away batters with consistency. His inability to work deep into games has exposed Colorado’s bullpen, often forcing them into action earlier than desired. While the Rockies have a few bats capable of making an impact at Coors Field, Brown’s lack of command has repeatedly put his team behind from the start. With Miami showing signs of life offensively and Weathers coming in with momentum, the Marlins appear better positioned on both the mound and at the plate.

Marlins vs Rockies Prediction: Marlins ML (-160) available at time of publishing. Playable to that number