Milwaukee Brewers vs Chicago Cubs Prediction, Odds and Picks for Today, 10/09/25

It’s time for Game 4 of the NLDS, as the Milwaukee Brewers will wrap things up against the Chicago Cubs. However, the Cubs aren’t likely to go quietly after picking up a win yesterday. Chicago has scored in the first inning of all three games in this series and will look to keep that momentum going behind Matthew Boyd, who’ll be taking the mound tonight. Boyd struggled in Game 1 against the Brewers, allowing 2 earned runs on 4 hits in just two-thirds of an inning. 

For the Brewers, Freddy Peralta will make his second start of this series after earning the win in Game 1, allowing just 2 earned runs over 5.2 innings. Offensively, the Brewers have outscored the Cubs 19-10 in this series, and Boyd will have his hands full trying to contain this lineup. The Brewers have been the consistent and complete team all season, and with Peralta on the mound, they’re well-positioned to close out the series and advance to the NLCS. 

Brewers vs Cubs prediction: Brewers ML (-120) available at time of publishing. Playable at that number.

You can bet on our Brewers vs Cubs pick with BetMGM, where right now new users can activate your new BetMGM account ⚡ and receive $150 in bonus bets INSTANTLY if your first $10+ wager is a winner!