Milwaukee Brewers vs Pittsburgh Pirates Prediction, Odds and Picks for Today, 09/06/25

It’s time for some Saturday baseball as the Milwaukee Brewers look to keep things rolling in game two against the Pittsburgh Pirates. Milwaukee took game one with a 5-2 win, keeping their 5.5 game lead in the NL Central. Brandon Woodruff will get the start for the Brewers today, entering with a 5-2 record and a 3.69 ERA. The last time Woodruff faced Pittsburgh, he pitched four scoreless innings and struck out four.  

For the Pirates, Mitch Keller gets the start, entering with a 6-13 record and a 4.21 ERA. The last time he faced the Brewers back on August 13, where he gave up six earned runs on eight hits across four innings. The Brewers rank second in the majors in runs per game this season (5.1), so Keller will have his hands full this afternoon. Woodruff has struggled a little bit in his last two starts, allowing 10 runs in his last 10 innings pitched, but this looks like a good spot for him to bounce back. I like Woodruff and the Brewers in today’s matchup, making them my best bet of the day. 

Brewers vs Pirates prediction: Brewers ML (-150) available at time of publishing. Playable at that number.