Milwaukee Brewers vs San Diego Padres Prediction, Odds and Picks for Tuesday, 09/23/25

The Milwaukee Brewers will turn to Bruce Zimmermann, who is making his first start of 2025. While Zimmermann has shown flashes of reliability in the past, his profile leans heavily toward contact, and that often leaves him vulnerable to hard hit balls and crooked innings. His ERA and WHIP have trended on the higher side, particularly when he falls behind in counts and is forced to challenge hitters. Against a Padres lineup that has the ability to capitalize on mistakes and string together rallies, Zimmermann will need to be exceptionally sharp to keep Milwaukee competitive. The Brewers’ offense has been able to produce at times, but asking them to overcome an early deficit against a strong San Diego club could be difficult.

On the other side, the Padres send out Randy Vasquez, who has been steady in his role this season, entering with a 5–7 record, 3.94 ERA, and 1.36 WHIP across 125.2 innings. Vasquez has mixed his repertoire well and is coming off an excellent outing against Colorado, where he delivered six scoreless innings and struck out nine while allowing just four hits. That kind of performance highlights his upside and gives San Diego confidence that he can control the tempo early in this game. The Padres’ offense, built around timely hitting and a balanced approach, has shown the ability to push across runs even in tighter, lower scoring contests. With Zimmermann’s inconsistency and Vásquez’s more reliable recent form, San Diego appears to hold the edge.

Brewers vs Padres Prediction: Padres ML (-115) available at time of publishing. Playable to -120