Milwaukee Brewers vs San Diego Padres Prediction, Odds and Picks for Today, 09/24/25

The Milwaukee Brewers and San Diego Padres will wrap up their 3-game series on Wednesday night as the Padres look to complete the sweep. Both teams have secured a spot in the postseason, but the Brewers only hold a 3-game lead for the best record in the National League. Taking the mound tonight for Milwaukee will be Chad Patrick, who enters with a 3-8 record and a 3.66 ERA. 

The Padres counter with Dylan Cease, who is 8-12 with a 4.64 ERA. Both pitchers have struggled this season, but Cease has the slight edge in tonight’s matchup. Offensively, the Brewers have struggled to get things going after clinching a playoff spot — averaging 4.3 runs per game compared to the Padres’ 5.6. Taking everything into consideration, the Padres have been on a roll and they should be able to complete the sweep with Cease on the mound before facing a red-hot Diamondbacks team. 

Brewers vs Padres prediction: San Diego ML (-125) available at time of publishing. Playable at that number.

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