Milwaukee Brewers vs St. Louis Cardinals Prediction, Odds and Picks for Today, 09/19/25

The Brewers aren’t letting up just yet, with one goal still on the table before the postseason: lock up the top seed in the National League. Milwaukee will make their way to St. Louis to open a three-game series with the Cardinals, and taking the mound for the Brewers will be Jacob Misiorowski who enters with a 5-2 record and a 4.35 ERA.

The Cardinals are expected to send Sonny Gray to the mound who enters with a 13-8 record and a 4.43 ERA. Both starters have struggled in recent outings – Gray holds a 1-1 record and a 6.61 ERA in his last three starts, while Misiorowski has gone 1-1 record and a 4.41 ERA in his last three starts. Offensively, the Brewers hold the advantage, averaging 5.9 runs per game in their last 10 games compared to the Cardinals 3.5. While the Cardinals playoff hopes are unlikely, they’re still going to give it their all to try and pick up a win. However, I think the Brewers offense and Misiorowski will be too much for Gray and the Cardinals to handle, making Milwaukee my best bet of the day. 

Brewers vs Cardinals prediction: Milwaukee Brewers ML (-120) available at time of publishing. Playable at that number.

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