Minnesota Twins vs Cleveland Guardians Prediction, Odds and Picks for Sunday, 08/03/25

It’s time for Sunday baseball as the new-look Minnesota Twins look to snap their four-game losing streak against the Cleveland Guardians. Cleveland has taken the first two games of the series and will be aiming for the sweep as they continue to play well in the second half of the season. Taking the mound for the Guardians will be the southpaw Joey Cantillo who enters with a 2-1 record with a 4.14 ERA this season. 

For the Twins, Jose Urena will get the start who’s struggled this season, going 0-0 with a 5.40 ERA. It’s been a journey for Urena this year as he’s been with the Mets, Blue Jays, Dodgers, and now the Twins. The Guardians aren’t exactly blowing their opponents out of the water, averaging just 3.9 runs per game this season – however, they have a solid bullpen that holds a 3.60 ERA this year that’s helped them close out some close games this season. At the end of the day, I think the Twins are going to have a tough time in the second-half of the season, and it won’t get any better for them today. Look for the Guardians to get ot Urena early on and complete the sweep, making Cleveland my best bet of the day. 

Twins vs Guardians prediction: Guardians ML (-165) available at time of publishing. Playable at that number.