Minnesota Twins vs Kansas City Royals Prediction, Odds and Picks for Today, 09/05/25

The Twins enter this matchup on Friday night against the Royals riding a 4-game losing streak. It’s been a rough season in Minnesota, and the Twins seemed to have signaled the start of a rebuild with their historic fire sale at the trade deadline. The Twins are going with a bullpen game in this one. That could be an uphill battle, as Minnesota’s bullpen ERA of 4.62 ranks 25th in the league. The Twins have struggled on the road all season long, owning a 27-42 record away from Target Field. Furthermore, they’ve won just 8 of their 21 road games since the All-Star break.

Michael Wacha will get the start on the mound for the Royals. The Royals won 5 consecutive starts of Wacha’s from July 26 to August 18 before dropping his last 2 outings. But, but of those came against the Tigers, who are a team that leads the AL Central by a wide margin. This outing comes against a Minnesota team that sits 18.5 games back in the division. The Royals haven’t exactly been on fire lately, but this is a very winnable game at home. Back the Royals here.

Twins vs Royals prediction: Royals ML (-135) available at time of publishing. Playable to -140.