Minnesota Twins vs Kansas City Royals Prediction, Odds and Picks for Saturday, 09/06/25

The Minnesota Twins and Kansas City Royals play on Saturday night, part of the Fox national telecast. The Royals won 2-1 on Friday, as they continue to hang around the playoff picture. The amazing thing about the Royals’ run is that they are basically doing it without any offense. They have scored the 3^rd-fewest runs of any team and the least in the AL, yet their pitching continues to hold up and give them a chance. Only the Rangers have allowed fewer runs. For the Twins, they have now lost 5 in a row, and they are looking for their ace to stop the bleeding. One notable factor in this game is that Bobby Witt Jr. left Friday’s game with back spasms. I would expect that to keep him out on Saturday, and if he misses this game, I am definitely in on the Twins. My Twins vs Royals pick is the Twins on the Money Line.

Joe Ryan had a couple of ugly starts in a row, but he got himself right in his last outing against the Padres. I expect him to be in good form Saturday, especially if Witt is out of the lineup. There just isn’t much firepower in this KC offense. He will face Stephen Kolek. Kolek has made a bunch of starts for the Royals as he has bounced between KC and the minors to fill rotation holes. He has been perfectly adequate for the Royals, and the bullpen behind him has been a top 5 unit all season. Scoring should be at a premium on Saturday, and there is nothing wrong with taking the under here, but I am backing the Twins if Witt sits.

Twins vs Royals Prediction: Twins ML (-125) available at the time of publishing. Playable at that number.

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