Minnesota Twins vs Philadelphia Phillies Prediction, Odds and Picks for Today, 09/26/25

After a disappointing season, the Minnesota Twins will make their way to Philadelphia for their final three games. The Twins will send their ace, Joe Ryan, to the mound, who enters with a 13-9 record and a 3.47 ERA. Despite having a great season, Ryan has struggled down the stretch, going 0-2 with a 9.00 ERA in his last three starts. 

For the Phillies, Taijuan Walker will get the nod, entering with a 5-8 record and a 4.18 ERA. The Twins have struggled offensively all year, and in their last 10 games, they’re averaging just 3.9 runs per game. For the Phillies, they’re slightly better, averaging 4.8 runs per game in their last 10. While this isn’t a must-win for the Phillies, they won’t just let the Twins win, as they still have a chance to take the top seed in the National League. The Phillies shouldn’t have any issues in this one and will take game one of this three-game set. 

Twins vs Phillies prediction: Philadelphia Phillies (-170) available at time of publishing. Playable at that number.

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