New York Mets vs San Diego Padres Prediction, Odds and Picks for Monday, 07/28/25

The Mets head to San Diego looking to extend their recent hot streak behind right hander Frankie Montas, who’s quietly been a reliable arm early in games. Montas owns a 4-1 NRFI record in limited starts this season, showing good command and the ability to limit damage out of the gate. New York’s offense, despite heating up overall during a seven game win streak, has struggled to produce early—ranking bottom third in MLB with just 52 first inning runs. Their .248 batting average and .317 OBP in the opening frame reflect a team that often needs a few innings to settle in offensively. Against a quality pitcher on the road, that trend could continue.

The Padres will counter with Dylan Cease, who has a 9-4 NRFI record in his last 13 games and remains one of the better strikeout pitchers in the league. Cease has held opponents to weak contact early in games and should match up well with a Mets lineup that ranks 8th worst in 1st inning scoring. San Diego’s offense, while improving in overall production, has also been relatively quiet in the opening frame, posting just 55 runs across 106 games, with only 10 home runs. With both starters showing strong early game control and neither lineup profiling as explosive in the first inning, this sets up well for a No Run First Inning.

Mets vs Padres Prediction: No Run First Inning (-115) available at time of publishing. Playable to -120.

👉🏼 CLICK HERE 👈🏼 to fade or follow our experts’ Mets vs Padres best bet at DraftKings Sportsbook and secure $150 in bonus bets as soon as you create an account!